The European Journal of Human Genetics (EJHG) is inviting submissions for a Special Issue on Hereditary Cancer. This issue will explore key advancements in the field, with a particular focus on polygenic risk scores (PRS) in cancer risk stratification, the role of precision oncology in hereditary cancer, innovative sequencing approaches, functional variant classification, and strategies for improving early detection and genetic testing accessibility. In addition to several commissioned articles, we welcome original research, reviews/perspectives that provide new insights into hereditary cancer, polygenic risk, and precision oncology in hereditary cancer. By bringing together diverse contributions, this Special Issue aims to highlight the latest scientific and clinical developments that may help understand the future of hereditary cancer care.