Neoliberalism is associated not only with rising inequality but also with rising insecurity. We describe an epidemic of work-related insecurity, associated in the first instance with deindustrialisation, noting that insecure work (such as the zero-hours contracts that have multiplied in the UK) has become the norm for many workers. However, we also note striking contrasts between labour market conditions in high-income countries, emphasising the importance of political and policy choices. Insecurity is not confined to labour markets. Access to adequate diets and shelter are key social determinants and health, and both are insecure for many people, as evident from increasing reliance on food banks and rising levels of homelessness, the criminalisation of which is becoming widespread. We conclude with a discussion of privatisation, another key element of neoliberalism, and its effect on security of access to health care through what has happened to England’s National Health Service.