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I started building models in my master's. At that time, my focus was on mathematical models of biological systems, not credit scorecards. I did a dissertation on metabolic engineering with a stoichiometric model of yeast metabolism. The objective was to identify parameters and fluxes to integrate with metabolite measurements. The system of equations was solved using quadratic programming (QP), also called metabolic flux balancing (MFB), which is a form of optimization modeling. Back then, I was more enthusiastic about the optimization software (GAMS) than about modeling yeast reactions. I was insistent with Dr. Kookos that I should work with the optimization model, not the stoichiometric equations; he grew weary and shared a crucial insight that has remained with me:

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Conceptual Representations

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  • 发表日期：

    2025年

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  • Saul Rodrigo Alvarez Zapiain

摘要

I started building models in my master's. At that time, my focus was on mathematical models of biological systems, not credit scorecards. I did a dissertation on metabolic engineering with a stoichiometric model of yeast metabolism. The objective was to identify parameters and fluxes to integrate with metabolite measurements. The system of equations was solved using quadratic programming (QP), also called metabolic flux balancing (MFB), which is a form of optimization modeling. Back then, I was more enthusiastic about the optimization software (GAMS) than about modeling yeast reactions. I was insistent with Dr. Kookos that I should work with the optimization model, not the stoichiometric equations; he grew weary and shared a crucial insight that has remained with me: