This study examines the factors influencing financial strain among listed basic chemical manufacturing companies in Vietnam over a six-year period from 2018 to 2023, with a particular focus on the impact of the COVID-19 pandemic. A dataset comprising companies listed on the HOSE and HNX exchanges was constructed and analyzed using Excel software. Descriptive statistics and regression analyses were conducted to investigate the relationship between various financial metrics and financial strain. The results indicate that Return on Equity (ROE) positively influences both the current ratio (CR) and quick ratio (QR), while the Leverage Ratio (LEV) negatively impacts CR. Furthermore, the Net Cash Flow from Operating Activities to Revenue Ratio positively affects CR. The study also finds that the COVID-19 pandemic has exacerbated the impact of the Leverage Ratio on financial strain. Based on these findings, recommendations are provided for listed companies to manage financial strain effectively.