The increasing urban population demands an increase in the count of buildings in cities. The present paper analyzes how wind and thermal comforts vary in a low-rise building cluster and high-rise building cluster. OpenFOAM CFD tool is used for simulation study. High-rise buildings are made with dimensions 60 * 30 * 90 m and low-rise with length and breadth the same as high-rise but height is of 20 m and the spacing between buildings is kept 90 m itself. Open terrain configuration with a 0° wind incidence angle is considered. The mesh resolution is in the order of 8–8.5 million cells. The flow is assumed to be incompressible, inviscid, and unsteady. The inlet profile is generated using log-law equation. The wind and temperature distributions surrounding buildings at five vertical levels of building heights and at the pedestrian level are compared between two clusters. The results show that at pedestrian level the magnitude of wind velocity in low-rise buildings is 19% less than that of the case with high-rise buildings. Also, the low-rise buildings experience lower temperature spread compared to high-rise buildings.