This study aims to explore how two C-shaped high-rise buildings interact with each other, specifically examining the impact on local pressure coefficients (CP) and mean pressure coefficients (CPMEAN) using computational fluid dynamics (CFD). Four scenarios are investigated based on the height of the interfering building (IB). The CP is assessed on the principal building (PB) and compared to an isolated building of the same shape and size. The interference effect on PB is quantified using the interference factor (IF). The findings reveal significant variations in the pressure coefficients on PB due to the presence of the interfering building. The minimum force coefficient (CF) on PB, occurring with an interfering height of 550 mm, is 0.082, representing an 88.11% reduction from the maximum CF. Similarly, the minimum moment coefficient (CM) on PB, also observed with a 550 mm interfering height, is 0.188, indicating an 80.69% decrease from the maximum CM. The study highlights the shielding effect of the interfering building, which generally leads to a reduction in CF on PB. Additionally, notable disparities in CPMEAN are observed on the face of PB. For instance, when the interfering height is 450 mm, the leeward face of PB exhibits the maximum CPMEAN of 0.34. These findings provide valuable insights into the aerodynamic interactions between C-shaped high-rise buildings, emphasizing the importance of considering interference effects in building design and urban planning.