Dietary supplements and nutraceuticals are a class of materials with properties and qualities more commonly associated with pharmaceuticals than with food. Nevertheless, there is currently no globally recognized definition for these food-therapeutic interfaces, and global perspectives on them can vary from region to region. In the majority of nations, nutritional supplements contain nutraceuticals. They might be biologically active phytochemicals with advantageous effects on health. The customer may receive this as functional food or as a supplement. The use of nutritional supplements is increasing at an exponential rate, thus understanding these items is essential. The current chapter deals with different influential factors like material collection, active component extraction, stability, and the impact of different material properties on the performance of dietary supplements or nutraceutical-based products. This chapter further focused on a variety of industrial manufacturing perspectives, including current market trends of dietary supplements or nutraceuticals, various techniques of manufacturing, and possible solutions for the problems associated with the manufacturing and regulatory aspects.