In recent years, the metallic sandwich panels especially with honeycomb core showed immense potential in blast load mitigation application due to their lightweight characteristics along with excellent energy absorption under impulsive loading. In this study, comprehensive investigation on dynamic behaviour of sandwich panel consisting of multilayers of honeycomb core has been conducted by means of numerical simulation. Here, the sandwich panel of honeycomb core having hexagonal topology is simulated numerically using LS-DYNA®. This study investigated the influence of multi-layered core on the blast performance of sandwich panel. Base on this study, it can be concluded that the multilayers of core with intermediate sheets enhance sandwich panel performance and enable the application of larger loads for the same configuration under blast loading.