This chapter delineates the potential applications of nicotinamide coenzymes and their precursors, elucidating their pivotal roles across various domains such as food supplement, cosmetics, chemical industry, agriculture, and pharmaceutical development. China has established large-scale industrial production of six related products, thereby laying a foundation for their diverse applications through the continual refinement of manufacturing processes. Within the health food industry, compounds such like NAD+, NR, NMN, and NADH are utilized as fundamental ingredients. Notably, NMN demonstrates significant potential in improving sleep quality and addressing colon cancer in murine models. In the realm of cosmetics, these substances are highly coveted for their pronounced effects in acne reduction, skin whitening, and anti-aging. In addition, in the food industry and agriculture, the application of nicotinamide coenzymes and their precursors augments the quality of food and the photosynthetic efficiency of plants, significantly contributing to the sustainable advancement of agriculture. Market analysis shows that the increasing health consciousness and technological progress are driving the global demand for these products, suggesting a favorable trend towards market expansion. The research and application analysis presented here provides both theoretical frameworks and practical strategies for the innovative development and commercialization of nicotinamide coenzymes and their precursors, underscoring their substantial academic and economic significance.