The present chapter encapsulates interactions of soil algae with various microbes. The nature and benefits of algae-microbial interactions are discussed briefly. The advantages and applications of algae-microbes mutual synergism are emphasized in this chapter. The interaction between soil algae-microorganism-plants resulted in the availability of nutrients, conditioning of soil, biofertilizers for plants, and improved crop production and plant defensive metabolites and pigments. The roles of microbial interaction with soil algae are to maintain soil fertilization and reduce the use of chemical fertilizers and pollutants in the soil. The chapter is intended to provide an overview of the benefits arising out of soil algae-microorganism-plants interaction.