This manuscript outlines the innovative ECOSTP® treatment design process, a sophisticated three-stage anaerobic system modeled after a cow’s stomach. The system combines wastewater from various sources and applies appropriate treatment to achieve quality as per the discharge standards by the regulatory authority. The ECOSTP structure consists of three interconnected chambers, each lined with roughness to increase the surface area in a similar way to a cow’s stomach. The second element of this process involves the role of facultative anaerobic fungi and anaerobic bacteria, which convert and clean sewage in the absence of oxygen. This system does not use any chemicals or energy sources for the treatment. Contrasting with aerobic digestions, the anaerobic process is highlighted as economical due to non-reliance on mechanized operations. However, promising potential challenges persist in replicating microbial communities and processes in diverse environmental conditions. Scaling up biomimetic systems to accommodate larger wastewater volumes introduces complexities, including ensuring consistent performance and durability. Additionally, environmental concerns such as methane production must be addressed through robust management strategies. Future research should focus on overcoming these technical challenges by exploring advanced methods for stabilizing microbial ecosystems and enhancing the adaptability of the system for varied wastewater profiles.