Any worrisome breast symptom undergoes triple assessment to rule out malignancy as the underlying cause. The assessment involves clinical examination, imaging evaluation, and histopathological assessment. Although pathological results remain the gold standard for the patient, these are limited by sampling errors and false-negative results. Thus, it becomes mandatory to have a radiology and clinical background for accurate rad-path correlation while interpreting the tissue specimens or slides. The imaging and pathologic findings are considered concordant when the pathologic result provides an acceptable explanation for the imaging feature and discordant when they do not. The radiologist performing the biopsy must be aware of the imaging features of a vast variety of pathologic breast lesions and must be able to correlate the imaging findings with pathology report. A good working relationship between the radiologist and the pathologist forms the cornerstone of a robust rad path correlation, which aims to improve the patients’ outcomes.