Nanotechnology has brought a revolution in all scientific fields, and dentistry is an essential field that greatly benefits from nanotechnology. In the oral cavity, nanostructures occur in particulates that are widely spread and are utilized as biomaterials. This chapter highlights the integration of nanomaterials in 3D printing applications of orthodontics, dental implants, and the surgical guide and template field. The current trends and future directions of the utilization of nanomaterials in 3D printing applications in orthodontics, dental implants, and surgical guide and template applications are provided. Various nanomaterials used to modify the properties of 3D printing materials used in orthodontics, dental implants, and surgical guides/templates to improve the biological, mechanical, and physical properties of the materials are discussed in detail along with the mechanisms by which they exert their biological/physical/mechanical enhancement effect on the 3D printing resin materials. The obstacles that need to be overcome to advance the utilization of nanotechnology in 3D printing applications of orthodontics and dental implants are discussed. Moreover, the future insights on the use of nanomaterials in improving the orthodontic and dental implant therapeutic technique were also provided.