In this study, efforts were made to understand the re-usability of plastic waste (PW) and glass waste (GW), as a construction material. In this regard, the assessment was done to understand the impacts of replacing cement and sand with the recycled GW and PW, on different properties of foamed concrete (FC), respectively. Experiments were designed using central composite design and optimization of process parameters i.e., cement-to-glass replacement (C-S- R) and sand-to-plastic replacement (S-P-R), and performed to achieve maximum compressive strength (CS). It was revealed that at optimized conditions i.e., C-S-R = 60% and S-P-R = 20%, the CS of FC improved to 5.03 MPa. At these conditions, bulk density, porosity and water absorption were reported to be 1389.12 kg m−3, 32.39% and 26.51%, respectively. Further, it was estimated that the use of PW and GW, as construction material, may prove beneficial in managing 19.11% increased COVID-associated bio-medical waste (BMW) and also reduce 14.18% carbon dioxide emissions. Therefore, it is proposed that in such unprecedented times, the re-use of PW and GW, as a construction material, need to be substantially encouraged.