Microfocused ultrasound (MFUS) has emerged as a device for noninvasive skin rejuvenation, but its current cosmetic usage has evolved from other intense frequency ultrasound (IFU) technology. High-intensity focused ultrasound (HIFU) was first discovered for thermal injury usage in the 1920s during World War II to kill schools of fish and was later studied in the 1940s for an alternative form of thermal tissue ablation in solid malignant or benign tumors [1, 2]. Additional clinical studies have shown HIFU as an effective treatment in patients with liver, pancreas, prostate, kidney, breast, and bone cancers [3]. This focused ultrasound technology from HIFU was then studied at lower energies in MFUS devices as a noninvasive cosmetic option to lift and tighten the dermal and subdermal tissue.