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In this research, we have formulated a mathematical model by employing a set of nonlinear ordinary differential equations (ODEs) to explain the dynamics of the disease psoriasis. As primary populations, we have considered the densities of two major sub-types of T-cells ( \(Th_1\) and \(Th_{17}\) cells) and keratinocytes. To ensure the importance of this cell replacement strategy, we have considered mesenchymal stem cells (MSCs) as a secondary population. Then we have observed from a mathematical point of view how the primary immune cells interact with MSC and how the cytokine storm will slow down with the effect of umbilical cord-derived MSC (UC-MSC) transplantation in a pulsed manner. Our theoretical investigation and the numerical findings may provide a new insight into psoriasis therapy approaches and may be proposed as a treatment policy for future clinical trials.

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Introducing MSC Therapy to Inhibit \(Th_1\) and  \(Th_{17}\) Mediated Cytokines: A Mathematical Study to Regulate Psoriasis

  • 会议论文

  • 发表日期：

    2025年

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  • Subhankar Kushary,
  • Priti Kumar Roy,
  • Xianbing Cao

摘要

In this research, we have formulated a mathematical model by employing a set of nonlinear ordinary differential equations (ODEs) to explain the dynamics of the disease psoriasis. As primary populations, we have considered the densities of two major sub-types of T-cells ( \(Th_1\) and \(Th_{17}\) cells) and keratinocytes. To ensure the importance of this cell replacement strategy, we have considered mesenchymal stem cells (MSCs) as a secondary population. Then we have observed from a mathematical point of view how the primary immune cells interact with MSC and how the cytokine storm will slow down with the effect of umbilical cord-derived MSC (UC-MSC) transplantation in a pulsed manner. Our theoretical investigation and the numerical findings may provide a new insight into psoriasis therapy approaches and may be proposed as a treatment policy for future clinical trials.