With the rapid increase in the number and scale of power transmission and transformation projects, the phenomenon of line proximity to residential areas has become increasingly common, and the phenomenon of transient electric shock is particularly prominent. In this paper, based on the transient shock mechanism, a circuit model of transient shock of a DC transmission line is established, and the extreme case of transient shock is simulated, in which the human body part is represented by an equivalent circuit module. The circuit model is used to simulate and calculate the transient process of transient electric shock, and the changes in induced voltage and discharge current are obtained. Then, an experimental platform for the transient shock of DC transmission lines was built to measure the discharge current of transient shock under different voltage levels of DC transmission lines, and the experimental results verified the effectiveness and usability of the designed model and method. Finally, this paper examines the differences in the effects of transient shocks on different parts of the human body. It has been found that the skin of the arms, head, heart, and feet of the human body is susceptible to electric currents during transient shocks.