To project Egypt's Vision 2030 and the United Nations' sustainable development goals in urban planning practice, this research investigates the application of the neo-arid city manifesto at an existing site in Cairo, Egypt. The manifesto correlates sustainable design strategies at the urban pattern and building scales to each other in one design phase to generate a neighborhood detailed plan that considers microclimate conditions as a base for city planning. Such comprehensive design focuses on adjusting the relation between fabric-space as well as environment-economy to intensify shading, and thermal mass insulation while considering low-cost construction trade-off at the environment-economy dimension. The proposed manifesto utilizes urban passive design in terms of court-yarded clustered free planning as an alternative design grain to substitute conventional back-to-back parcel. Urban courtyards as a main urban morphology and design grain element are characterized by; 1) linear and semi-compact patterns with clustered and micro-climatically adjusted housing typology; 2) thermal resistant and mass walls with attached and semi-attached passive housing units; 3) low-cost eco-friendly materials and bearing wall construction using Stabilized Compressed Earth Blocks (SCEB) having the majority of its mixture of clay complete the passive design on the urban-building dimensions; and 4) applies photovoltaic renewable energy on roofs based on the initially adjusted pattern orientation. A bundle of dynamic and numerical simulations took place. Results showed improved indoor-outdoor environmental conditions with a reduced air temperature of 1 ℃-1.4 ℃ respectively. 10 ℃ pedestrian thermal comfort drop variance was noticed. 16.16 ℃ mean radiant temperature cut, and 475 w\m2 global radiation differences at peak hours. Further, it can be said after another design experiment of the same paradigm that the generated urban form expresses a NEO revitalization of the traditional courtyard into a neighborhood scale with improved sustainable measures on its other urbanism coin side.