Sustainable University campus design is a growing area of interest as universities seek to reduce their environmental impact and create more healthy and livable spaces for students, faculties, and staff. This research delves into a case study of a groundbreaking and environmentally conscientious university campus in Egypt, utilizing simulation modeling for one of the campus's faculties. The overarching design concept revolves around establishing parity among all professions and conveying a clear message that all professions complement one another to form a cohesive community. Any missing profession would result in an incomplete representation of the community. This concept is realized by integrating all university campus facilities into a central interactive plaza that brings together students from all majors. The case study design is rooted in the principles of sustainability (social, environmental, and economic). The university campus design incorporates several groundbreaking sustainable design features, encompassing green spaces, harmonious integration of faculties and other elements, utilization of sustainable building materials, and energy-efficient buildings and systems. A computational fluid dynamics (CFD) simulation was performed for a single faculty building to model natural ventilation airflow, assess thermal comfort, and evaluate faculty energy consumption. The simulation findings demonstrate that the proposed design achieves a 45% reduction in energy consumption compared to conventional designs, while simultaneously ensuring user thermal comfort, fostering integration with nature, and maximizing reliance on natural lighting and ventilation.