The construction sector is among the primary generators of material waste, responsible for more than one-third of the volume recorded worldwide. Due to the high demand for infrastructure development, the numbers are expected to increase. Therefore, waste reduction at any stage is essential to comply with global sustainability targets. However, it has been recognized that design-related factors cause more than 32% of the construction waste. Hence, enhancing sustainable construction design practices is essential to mitigate the problem. This can be supported by better engineering practices in the construction design as the study delves into the exploration of effective utilization of materials and waste reduction in construction such as designing for deconstruction, flexibility, standardization, and durability; designing out of waste and selecting reclaimed materials. The present study scrutinizes opportunities for efficient materials use and the reduction of material waste in construction activities through the identification of novel design strategies.