Debrining is one of the most important steps in the construction of a salt cavern. Aiming at the problems of debrining parameters prediction and optimization, this chapter carried out the following research: (a) A debrining model of a gas storage salt cavern to predict the debrining parameters and salt deposit growth based on the crystallization kinetics and heat transfer principle is built. (b) The variation rules of debrining parameters were analyzed, and the model was validated by debrining monitoring data. (c) The morphological and hydraulic characteristics of sediments are quantitatively analyzed by a series of experiments. (d) A model for calculating the minimum moving critical velocity of irregular sediment particles is established. Preventive measures for the clogging of debrining inner tubing (DIT) are proposed. (e) The salt deposits growth rules were analyzed during debrining, and the method for preventing the DIT blocked by salt deposits is proposed. Research results provide a technological reference for preventing clogging of DIT and the optimization of debrining parameters.