Soybean is one of the most popular food in India, where most of the people are vegetarian, fats and proteins that come from plants are especially important. It is affected by different diseases, but rust is the most dangerous one. Since the beginning of agriculture, people have had to contend with recurrent outbreaks of crop rust. As a direct consequence of this, cereal rust infections were among the very first to get extensive research as the field of plant pathology developed during the 1800s and into the early 1900s. It was quickly discovered that the rust fungus was refered to as “shifty enemies,” a phrase coined by E. C. Stakman. These fungi had a persistent ability to generate new virulences that were capable of defeating freshly introduced resistant cultivars. However, a new science of disease stabilization and management is currently coming into being. This new science makes use of an increased understanding of the complexity of rust disease in order to halt the creation of harmful new virulences, to delay epidemics, and to reduce losses. This chapter presents the information that serves as the foundation for the new tactics that have been developed regarding soybean rust.