Intercropping with compatible cultivars may offer a sustainable solution for maximizing yield while minimizing pest damage. This research sought to determine how intercropping corn with soybeans affected nematode populations in the soybean rhizosphere under sandy soil circumstances. The findings demonstrated that growing soybeans alongside corn increased the amount of soybean seed produced per ha by lowering the overall numbers of azotobacter and nematodes in the soybean rhizosphere. Concerning the total counts of azotobacter and nematodes in the soybean rhizosphere as well as the soybean seed yield/ha, the corn cultivar S.C. 166 performed better than the other corn cultivars. Conversely, although azotobacter and nematode populations in the soybean rhizosphere were generally higher, the soybean cultivar Giza 35 yielded less seed per ha than other cultivars. In terms of total counts of azotobacter and nematodes as well as seed production per ha, it was shown that there was a high correlation between cropping tactics and the cultivars of corn and soybeans. Additionally, growing soybean cultivar Giza 22 alongside corn cultivar S.C. 166 enhanced total productivity and land consumption under the intercropping system of two corn and four soybeans while also reducing the overall count of nematodes. This suggests that the choice of cultivars and cropping systems can significantly impact overall productivity and pest management in agricultural systems.