Bacterial pustule disease caused by the pathogen Xanthomonas citri pv. glycines is a global threat to soybean cultivation. This chapter comprehends the historical context about pathogen and its taxonomy, in-depth exploration of disease symptomatology, epidemiology, and mitigation strategies. The spectrum of symptoms is dissected while shedding light on structural and physiological implications on the host. The determinants of virulence and mechanisms of pathogenesis employed by the bacterium are briefly highlighted including Type III secretion system, effector translocation, and quorum sensing. Further, an overview on epidemiology and management of the bacterial pustule disease via conventional, modern, and innovative approaches is presented, besides highlighting the need for convergence of the cutting-edge research and practical approaches to mitigate the impact of disease has also been highlighted.