In order to promote the intrinsically safe design of non-lethal kinetic energy projectile, an optimization design study was carried out for 38 mm hollow spherical non-lethal kinetic energy projectile. The impact rigid wall experiment of solid spherical projectile was used to complete the indirect verification of the projectile material parameters. The projectile wall thickness of 5, 7, 9, 11 and 13 mm was set respectively. Based on ANSYS LS-DYNA software, the changes of velocity, kinetic energy, radius, specific kinetic energy, VCmax value, energy transfer ratio and other data under five kinds of wall thickness were analyzed. The results showed that when the thickness, density, and impact velocity were separately set as 11 mm, 0.998 kg/m3, and 100 m/s, the wounding power of the projectile did not exceed the threshold of specific kinetic energy and VCmax value. Which provided the parameter support for the hollow spherical non-lethal kinetic energy projectile sample processing.