In building construction, the adoption of inclined slabs diverges from traditional horizontal ones due to differing support placements, resulting in sloped or angled surfaces. Despite their architectural significance, both inclined and horizontal slabs play vital roles as essential components in building structures. Functioning as slender flexural members spanning supports, they evenly distribute loads and support the weight of the structure. However, their vulnerability to hazards like touch-off explosions, such as suitcase bombs, package bombs, or improvised munitions, highlights the necessity of accurately predicting their response to extreme events. The lack of research on the response of inclined slabs to touch-off explosions in scientific literature has intrigued the authors. Understanding the damage mechanisms in inclined slabs presents an opportunity to enhance structural resilience and minimize the impact of such events in built environments. In this research work, the Abaqus software tool is employed to replicate the behavior of a horizontal slab, devoid of any inclination, supported solely by two parallel edges, when subjected to a touch-off explosion atop its centroid. This simulation closely follows the experimental protocols outlined by Zhao et al. (2019), wherein equivalent material properties, reinforcement arrangements, boundary constraints, explosive quantities, dimensions, configurations, and other relevant parameters are embraced. The blast is emulated using the Eulerian–Lagrangian approach, employing Finite Element Method (FEM) with the Abaqus tool. The accuracy of the model is verified through a rigorous comparison with experimental findings. Subsequently, the investigation’s purview is expanded to examine the impact of inclination angle within the same explosive scenario. To achieve this objective, various degrees of inclination, namely 5, 10, and 15°, are deliberated, and the behaviors of the inclined slabs are meticulously juxtaposed with those of the validated horizontal slab. Results showed that the distribution and mode of damage in inclined slabs vary significantly with angle of inclination. At angles of 5 and 15°, cracks are denser towards the lower support level, while at 10°, this trend is reversed. Flexure-shear mode dominates at both support levels for 10°, whereas at 5 and 15°, flexure-shear mode prevails at the lower level and shearing at the higher support level.