Blepharitis and keratitis are common ophthalmologic conditions that may present acutely or chronically in primary care settings. If left untreated, both can significantly compromise visual health, potentially leading to complications such as corneal ulcers, scarring, and even vision loss. Prompt and thorough assessment is therefore crucial to ensure timely diagnosis and management, helping to prevent long-term ocular damage and preserve visual function. This chapter outlines the clinical approaches and therapeutic strategies for managing blepharitis and keratitis effectively.