This article serves as a practical guide for general practitioners on the screening, diagnosis, management, and control of pulmonary tuberculosis (PTB). It emphasizes the importance of screening high-risk groups and close contacts using clinical assessment, radiological imaging, and laboratory investigations. Diagnostic approaches focus on identifying Mycobacterium tuberculosis through imaging and microbiological tests. Management includes first- and second-line treatment regimens, with an emphasis on patient adherence, monitoring for side effects, and implementing preventive measures such as BCG vaccination and contact tracing. Additionally, the article outlines referral criteria for complex or refractory cases. This guide equips primary care physicians with essential knowledge to effectively manage PTB across diverse clinical settings.