Chronic Kidney Disease (CKD) is defined by a sustained reduction in kidney function—with or without markers of kidney damage—persisting for more than three months. This chapter serves as a practical guide for general practitioners, focusing on the identification, classification, and management of CKD. Key topics include diagnostic criteria, classification systems, screening methods, identification of underlying etiologies, and management strategies. Recommendations for timely referral to specialists in advanced or rapidly progressing cases are also provided. To support clinical practice, this chapter highlights practical memory aids such as the 5C framework (Complaints, Compliance, Control, Complications, Comorbidities), the AEIOU indications for urgent kidney replacement therapy, and the ABCD-R approach (Anemia, Bone/Mineral Disease, Complications, Diet, Risk Reduction). While optimal CKD care often requires a multidisciplinary approach, this chapter offers streamlined, evidence-informed strategies to help busy general practitioners manage CKD effectively across diverse clinical settings.