Chronic pancreatitis results from repeated inflammatory episodes leading to fibrosis and progressive loss of both endocrine and exocrine pancreatic function. Clinical manifestations include chronic abdominal pain (often with waxing and waning exacerbations), pain radiating to the back, bloating, diarrhea, steatorrhea, weight loss, malabsorption, and diabetes mellitus. These contribute to reduced quality of life and decreased life expectancy. Alcohol remains the single most important cause in the majority of adult cases. Pancreatic function tests can aid in diagnosis. The primary goals of treatment are effective pain management and control of malabsorption.