Diarrhea is a common clinical problem in primary care but often presents a diagnostic challenge. A thorough history and physical examination are essential in identifying underlying causes, which can range from self-limiting illnesses to life-threatening conditions. This chapter offers general practitioners a holistic approach to managing diarrhea, supported by a simplified algorithm designed for use in busy clinical settings. It is based on multiple well-established sources of evidence, carefully tailored to meet the needs of primary care practitioners.