The clinical evaluation and investigation of peripheral neuropathy is a common challenge encountered by general practitioners. An approach guided by the duration of symptoms, clinical features (motor, sensory, mixed, or autonomic), anatomical distribution, and potential precipitating factors helps determine appropriate investigations and management. In cases with mild symptoms and an identifiable underlying cause—such as diabetes mellitus, alcohol use, or chemotherapy—a detailed workup is often unnecessary. Treatment focuses on addressing the underlying condition and relieving associated symptoms.