Acute coronary syndrome (ACS) is a cardiovascular emergency that demands prompt intervention. Timely recognition and accurate interpretation of early clinical signs and symptoms are essential for expediting treatment and improving outcomes. Equally important is the identification of risk factors and the implementation of secondary preventive strategies, which are integral to comprehensive ACS management. This chapter provides a concise overview of the detection, management, and monitoring of ACS, structured through a step-by-step algorithm to guide clinical decision-making.