Enuresis, or involuntary urination during sleep, is managed through behavioral strategies, pharmacological treatment, and addressing comorbidities. First-line therapy includes bedwetting alarms, which require consistency and family support. Bladder and bowel diaries help track contributing factors. Desmopressin is effective for short-term control, while anticholinergics or tricyclic antidepressants are reserved for refractory cases. Treating coexisting conditions such as ADHD can improve outcomes. Referral is indicated for non-monosymptomatic enuresis, complex secondary causes, or treatment failure. Long-term success depends on individualized care, caregiver involvement, and adherence to therapy. Relapse prevention strategies such as "overlearning" may help maintain dryness after successful treatment.