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Multiple confounding factors increase the difficulty of treating anemia in patients with systemic lupus erythematosus (SLE). Here, we described a 39-year-old female patient with SLE and lupus nephritis (LN) suffering from complications of anemia, acute kidney injury, and infection. During the treatment period, she received 120 mg roxadustat orally three times per week. Her hemoglobin (HGB) level steadily increased from 56 to 151 g/L. After the dosage of roxadustat was reduced to 50 mg three times per week, the HGB level gradually decreased and remained at 132 g/L. In this complicated case, roxadustat exhibited efficacy in treating anemia in a patient with autoimmune disease and infectious complications.

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Treatment of Anemia in a Lupus Nephritis Patient with Renal Insufficiency, Infection, and Bone Marrow Hypoplasia

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  • 发表日期：

    2025年

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  • Min Wu,
  • Ri-Ning Tang,
  • Bi-Cheng Liu

摘要

Multiple confounding factors increase the difficulty of treating anemia in patients with systemic lupus erythematosus (SLE). Here, we described a 39-year-old female patient with SLE and lupus nephritis (LN) suffering from complications of anemia, acute kidney injury, and infection. During the treatment period, she received 120 mg roxadustat orally three times per week. Her hemoglobin (HGB) level steadily increased from 56 to 151 g/L. After the dosage of roxadustat was reduced to 50 mg three times per week, the HGB level gradually decreased and remained at 132 g/L. In this complicated case, roxadustat exhibited efficacy in treating anemia in a patient with autoimmune disease and infectious complications.