Materials like zinc oxide, mesoporous silica, covalent organic frameworks (COFs), and metal-organic frameworks (MOFs) have expanded greatly and are emerging as important nanobiomaterials. The unique properties of porous nanobiomaterials like biocompatibility, low toxicity, tunable pore ordering, large surface areas, biodegradability, stable aqueous dispersion, and the ability to control the physicochemical properties make them attractive candidates for revolutionizing various aspects of healthcare. In addition to that, these nanobiomaterials possess high loading capacity which is suitable for drug delivery and cancer immunotherapy applications. Nonetheless, porous materials are also useful as antibacterial coatings. In this book chapter, we aim to highlight the importance of porous nanobiomaterials with regards to the biocompatible properties, efficient drug delivery, implants, bioimaging, wound healing, tissue engineering, and theragnostic and clinical translation for biomedical applications.