Nanotechnology, characterized by its dynamic nature, has emerged as a focal point in material science research with significant applications in agriculture. The global surge in nanoparticle production reflects the swift evolution of this field, marked by innovations such as nanopesticides, nanofertilizers, and nanosensors aimed at enhancing agronomic practices. Silver nanoparticles (AgNPs), a widely recognized nanomaterial, find applications in agriculture, showcasing potential benefits in plant growth, seed germination, stress tolerance, pest control, and mitigating microbial infections. Additionally, AgNPs play a crucial role in alleviating abiotic stresses, particularly drought, by regulating water balance, enhancing photosynthetic efficiency, and activating antioxidant defense systems. Understanding the molecular mechanisms underlying the interaction between AgNPs and drought-responsive genes remains a research challenge. Current studies indicate that AgNPs modulate gene expression, especially those associated with stress response and phytohormone signaling pathways. While AgNPs show promise in enhancing crop resilience to drought, concerns about environmental impact and nanoparticle accumulation in edible plant parts underscore the need for rigorous evaluation methodologies. Ongoing research is crucial to establish safety limits and address environmental considerations, ensuring the responsible and sustainable use of nanotechnology in agriculture.