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In the realm of pharmaceuticals and biotechnology, the science of drug delivery and therapeutic efficacy has undergone a remarkable evolution over the past few decades. Central to this progress has been the advent of PEGylation, a groundbreaking technology that has revolutionized how drugs are administered and their pharmacokinetics optimized. However, as with any revolutionary concept, the limitations and drawbacks of PEGylation have become increasingly apparent. This has prompted a new wave of innovation and exploration in the field, seeking alternative strategies and technologies to go “Beyond PEGylation”. In this discussion, we delve into the world of PEGylation and its alternatives, exploring the current state of the art, the challenges it presents, and the novel approaches that promise to reshape drug delivery and therapeutic strategies in the future.

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Beyond PEGylation “PEGylation and its Alternatives”

  • 章节

  • 发表日期：

    2025年

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  • Sehasree Mohanta,
  • Anuja Muley,
  • Mansi Upadhyay,
  • Dwiptesha Dahake,
  • Muktika Tekade,
  • Aprameya Ganesh Prasad,
  • Rakesh Kumar Tekade

摘要

In the realm of pharmaceuticals and biotechnology, the science of drug delivery and therapeutic efficacy has undergone a remarkable evolution over the past few decades. Central to this progress has been the advent of PEGylation, a groundbreaking technology that has revolutionized how drugs are administered and their pharmacokinetics optimized. However, as with any revolutionary concept, the limitations and drawbacks of PEGylation have become increasingly apparent. This has prompted a new wave of innovation and exploration in the field, seeking alternative strategies and technologies to go “Beyond PEGylation”. In this discussion, we delve into the world of PEGylation and its alternatives, exploring the current state of the art, the challenges it presents, and the novel approaches that promise to reshape drug delivery and therapeutic strategies in the future.