Scholarlink

PEGylation refers to the technique of modifying protein and peptide drugs with PEG, which offers numerous advantages over their unmodified counterparts in terms of physicochemical properties and therapeutic efficacy. This book chapter aims to equip the readers with detailed insights into objectives, methods, and end applications of PEGylation. The chemistry-related aspects of PEGylation, with special emphasis on the site of PEGylation, is the central theme of this piece of literature. Various critical factors affecting the process of PEGylation and its outcomes, such as the structure of PEG and size of PEG, have been emphasized in this manuscript. The applications of PEGylation in active and passive targeting and various FDA-approved PEGylated products are thoroughly discussed.

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

PEGylation of Therapeutic Proteins and Peptides

  • 章节

  • 发表日期：

    2025年

查看全文
  • Natasha Akojwar,
  • Ankit Mishra,
  • Pranali Mishra,
  • Muktika Tekade,
  • Shubham Ramdas Mule,
  • Rakesh Kumar Tekade

摘要

PEGylation refers to the technique of modifying protein and peptide drugs with PEG, which offers numerous advantages over their unmodified counterparts in terms of physicochemical properties and therapeutic efficacy. This book chapter aims to equip the readers with detailed insights into objectives, methods, and end applications of PEGylation. The chemistry-related aspects of PEGylation, with special emphasis on the site of PEGylation, is the central theme of this piece of literature. Various critical factors affecting the process of PEGylation and its outcomes, such as the structure of PEG and size of PEG, have been emphasized in this manuscript. The applications of PEGylation in active and passive targeting and various FDA-approved PEGylated products are thoroughly discussed.