This research examines the different design processes used by students in a bio-design course over a period of 3 years, respectively. The bio-design studio is part of the third year as part of the interior design studio which is focused more towards multidisciplinary exploration in design. The purpose of the design studio is to let students not only explore the idea of bio-design but go deeper into understanding the possibilities and extremities of connecting design with science. The studio gives an opportunity to the design students of exploring a multi-disciplinary venture, allowing information and influences from other disciplines such as visual communication, product design, engineering, new media, and digital, even interaction design. Bio-design as a course is focused largely on looking at the biological phenomena at all levels in the ecological system. The study focuses on analysing, exploring, and comparing the course methodologies and different design processes adopted by students of 3 batches over a period of 3 years, respectively. It also focuses on whether a particular design process helps students to derive design solutions conveniently. The study shall further analyse the student design process works in bio-design and explore how every design process eventually has helped the students develop multiple concepts, at the same time explore different parts of the biological system and its natural beings.