MXenes, discovered in 2011, are two-dimensional transition-metal carbides, nitrides, and carbonitrides that have attracted considerable attention owing to their promising features and applications in flexible and wearable smart textiles. They show superiorities such as ionic conductivity, hydrophilicity, mechanical flexibility, optical properties, robust surface functional groups, large surface area and unique surface chemistry. Several novel synthesis strategies have been investigated to obtain MXene-based flexible devices with various functions and tailored structures. Since its recognition, more than 30 distinct arrangements have been produced via selective etching of various MAX phase precursors. In this review paper, a comprehensive discussion on structural patterns, synthesis of the most researched MXene titanium carbide (Ti3C2Tx), properties, recent developments, and applications in smart textiles are presented. The major applications include healthcare, flexible energy storage, smart thermotherapy, supercapacitors, electromagnetic interference (EMI) shielding, water purification, biomedical, electrocatalysis, etc. In addition, existing challenges, and future research of MXene enabled e-textiles are also outlined.