Nowadays, health and human well-being are increasingly becoming core issues in the fields of design and architecture. Designers should focus not only on the beauty and functionality of space but also on its impact on people’s health and happiness. This study explores the importance of introducing Human-Centered Design concepts and considerations of human health and well-being into teaching human living environment design. The workshop’s primary objectives were to define and design home environments to maintain and promote health and well-being. To this end, an initial research phase based on trend research, personas, scenario-based design, and task analysis led to the definition of user needs and the context of use. Subsequently, each group discussed the results with the tutors to outline inputs and generate ideas. The article presents some case studies of home environments aimed at maintaining and promoting health and well-being. To conclude, results indicate that this teaching method significantly improves participants’ design thinking and problem-solving skills, especially when dealing with complex issues related to health and well-being. In summary, integrating health and human well-being considerations and Human-Centered Design concepts into residential environment design education can effectively improve professional skills and innovation capabilities while providing new directions for the future development of the interior design field.