In the realm of health care, spatial design plays a crucial role in shaping the patients’ journey within hospitals. The arrangement of spaces, use of color schemes, lighting techniques, and integration of natural elements all contribute to creating an atmosphere that can either enhance or hinder healing processes. As researchers increasingly recognize the significance of environmental factors on patient outcomes, understanding how spatial design shapes these journeys becomes paramount for improving health-care delivery and overall patient satisfaction. This paper aims to investigate the potential role of the emergency department (ED) layout in influencing the patient’s movement. Understanding the influential spaces of layout and flow on patient experience within hospital is important for creating environments that promote healing and well-being. To achieve this aim, the methodology consisted of comprehensive literature review and primary case study. The literature study focused on types of disasters along with their impact on hospitals. Numerous codes, standards and guidelines were considered for Disaster Management and Hospital Safety. Primary case study involved observation method and Focused Group Discussion Method to extract the condensed information from the stakeholders. The assessing characteristics such as patient movement, connectivity, privacy, perceptibility, duration, and circulation were considered. The outcome of the study highlighted important indicators at site, building and unit level which played a crucial role in the movement and circulation of the patients. The results of the study are an excellent source of information for health designers, which play a vital role in ensuring that patients have a safe and healthy environment.