Over the last two decades, scholars are interested in microchannel due to its uniquely designed feature, and now, a variety of applications are coming under knowledge. Our current research is focused on microchannel exploration for use in producing hydrogen using steam reforming using the methanol process. In this study, the vapour quality and homogeneity of water and methanol are assessed in a serpentine microreactor with V-inlet ports using COMSOL Multiphysics. The concentration of individual species (water and methanol) and vapour quality are measured along microchannel arc length with different parameters (heat flux, mass flow rate, concentration of individual species). In microchannel, the water–methanol solution gets vaporized at 200 mm of arc length at 120 W/m2 heat flux (523 K); i.e. vapour quality is coming to be unity. The difference in concentration of both the species is towards zero when the mass flow rate is decreasing and also witnesses a high mass fraction of hydrogen at the low mass flow rate, and zero difference in the concentration of species becomes a witness of homogeneity. The effect of different concentrations is observed with different concentrations of individual species and found that the mixture in microchannel neutral solution is achieved when the concentration of species is decreasing.