In our country, there are 60 billion square meters of existing leasable area, reactive powder concrete (RPC) has the characteristics of high toughness and high strength-to-weight ratio. RPC strengthened concrete (RC) forms RPC-RC structure, it is an important way for sustainable development of civil engineering to improve the anti-explosion ability of building structure while strengthening and reforming the structure. The dynamic response and damage assessment methods of RPC-RC columns subjected to blast loading are not clear. In order to solve this problem, the dynamic response of RPC-RC column under blast loading is simulated by using LS-DYNA finite element software, the Pressure-Impulse curve of RPC-RC column is established by using simplified numerical method, and the parameters of Pressrue-Impulse curve are analyzed. Finally, based on the results of parameter analysis, the formulas for calculating the overpressure asymptote and impulse asymptote are obtained, and the damage assessment method for RPC-RC columns is established.