Inflammatory pseudotumor of the liver (IPL) is a rare, benign, non-tumor mass characterized by fibrous tissue and myofibroblasts with inflammatory cell infiltration, predominantly plasma cells. The etiology remains unclear but may involve infections, inflammatory responses to trauma, IgG4-related diseases, and systemic inflammatory conditions. In recent years, some scholars have also referred to IPL as hepatic inflammatory myofibroblastic tumor. Clinical presentation is often nonspecific, affecting individuals across all ages but more frequently in children and young adults, and includes symptoms like right upper abdominal pain, fever, and weight loss. Diagnosis of IPL is challenging due to its varied imaging manifestations on modalities like CT, MRI, and ultrasound. These manifestations lack specificity and require a thorough analysis in conjunction with clinical and pathological features. On imaging, IPLs are typically solitary, with varied enhancement patterns reflecting their diverse pathological components. Dynamic scans offer insights into blood supply and pathological components, aiding differentiation from malignancies like hepatocellular carcinoma and cholangiocarcinoma. Accurate diagnosis is imperative to prevent unnecessary surgical interventions, with biopsy often necessary for definitive diagnosis when clinical and imaging findings are suggestive of IPL.

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Hepatic Pseudotumor

  • Liping Liu,
  • Yaoping Li,
  • Xinjiang Liu

摘要

Inflammatory pseudotumor of the liver (IPL) is a rare, benign, non-tumor mass characterized by fibrous tissue and myofibroblasts with inflammatory cell infiltration, predominantly plasma cells. The etiology remains unclear but may involve infections, inflammatory responses to trauma, IgG4-related diseases, and systemic inflammatory conditions. In recent years, some scholars have also referred to IPL as hepatic inflammatory myofibroblastic tumor. Clinical presentation is often nonspecific, affecting individuals across all ages but more frequently in children and young adults, and includes symptoms like right upper abdominal pain, fever, and weight loss. Diagnosis of IPL is challenging due to its varied imaging manifestations on modalities like CT, MRI, and ultrasound. These manifestations lack specificity and require a thorough analysis in conjunction with clinical and pathological features. On imaging, IPLs are typically solitary, with varied enhancement patterns reflecting their diverse pathological components. Dynamic scans offer insights into blood supply and pathological components, aiding differentiation from malignancies like hepatocellular carcinoma and cholangiocarcinoma. Accurate diagnosis is imperative to prevent unnecessary surgical interventions, with biopsy often necessary for definitive diagnosis when clinical and imaging findings are suggestive of IPL.