Cardiovascular disease ranks among the leading causes of mortality worldwide. Despite significant advancements in clinical research, numerous enigmas surrounding cardiovascular disease persist unresolved, driving the continuous pursuit of novel diagnostic and therapeutic approaches. The recent development of aggregation-induced emission luminogens (AIEgens) has led to significant progress in various aspects of this particular field, including biosensing, diagnosis, bioimaging, and treatment. AIEgens offer numerous compelling advantages in biological applications, such as high brightness, minimal background interference, superior signal-to-noise ratio, remarkable photostability, outstanding biocompatibility, and aggregation-enhanced therapeutic efficacy. This chapter surveys the application of AIEgens in angiography, as well as in the detection, diagnosis, and treatment of cardiovascular diseases. In particular, AIEgens could serve as probes for second near-infrared and multi-photon vascular imaging, detection of reactive oxygen species, diagnosis of atherosclerotic plaque, integrated diagnosis and treatment, and blood-vessel closure via photodynamic therapy process.