Redox reactions support processes such as maintaining homeostasis and metabolic functions in cells, making it possible for the plants to perfuse oxygenated conditions. The balance, however, could be interfered with by exogenous prooxidants, especially herbicides, which produce excess reactive oxygen species (ROS), leading to oxidative stress. Herbicide use, which is normally meant for weeds, also causes lipid peroxidation followed by cell death, which hinders the development and productivity of a plant. In terms of herbicide tolerance, crop plants possess certain enzymatic systems like cytochrome P450. On the contrary, excessive application of these chemicals into and onto the environment may negatively affect it and the non-target organisms, including farmers, through indirect effects. Studies have proven that prooxidant herbicides like glyphosate induce oxidative stress among agricultural workers; consequently, there are health-related issues, including respiratory disorders and other oxidative stress-associated conditions. This chapter calls for urgent attention toward alternative, eco-friendly weed management, like bioherbicides, to reduce health and environmental risks from synthetic herbicides.