Oxidative stress significantly influences the emergence of several diseases in humans. The two main factors, including the production of reactive oxygen species (ROS) and intracellular defense responses, constitute the maintenance of intracellular oxidative equilibrium. Elevated levels of oxidative stress can potentially modify lipid, protein, and DNA, leading to inflammatory responses and apoptosis. Studies demonstrate that oxidative stress is a significant factor in the occurrence of numerous types of cardiovascular conditions, including atherosclerosis, myocardial infarction, hypoxia, hypertension, and atrial fibrillation. Multiple treatment approaches are available to address cardiovascular disorders associated with oxidative stress. The study examined widely recognized antioxidants like dietary supplements and more peculiar antioxidants. Furthermore, innovative treatment approaches employing cardiac patches and miRNA have become available to address various cardiovascular conditions. This chapter provides a complete overview of oxidative stress and its consequences. Then, the discussion will delve into the correlation between oxidative stress and various heart diseases. Finally, we turned our attention to the clinical implications of oxidative stress in cardiovascular disorders.