Pipelines are one of the most critical facilities in the main building of thermal power plant, yet research on their seismic performance is very limited. To investigate the seismic performance of the pipelines within structure, methods using beam element instead of entity element achieved significant computational resource savings and time reduction in Abaqus, while maintaining consistency in analysis results. Subsequently, two models of the entire building were established: One model assumed the pipelines as mass points, while the other realistically modeled the pipelines and hangers using beam elements Results show that pipeline does not significantly influence the response of the structure. Based on these results, a fragility analysis was conducted, with pipeline stress to be engineering demand parameter, demonstrated the pipeline’s working status under varying earthquake impact.